| ncRNA name | hsa-miR-200b |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs); human embryonic kidney cell line HEK293A |
| Methods | microarray, luciferase reporter assay, ELISA, tube formation assay, immunohistochemistry, in situ hybridization |
| Expression pattern | down-regulated |
| Functional description | In the retina, miR-200b was localized in neuronal, glial, and vascular elements. Transfection of endothelial cells and intravitreal injection of miR-200b mimic prevented diabetes-induced increased VEGF mRNA and protein. Also prevented were glucose-induced increased permeability and angiogenesis. |
| PubMed ID | 21357793 |
| Year | 2011 |
| Title | MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy. |
| Drug-related ncRNA | NO |
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